CBD and THC: promising remedies for aluminum-related neurological damage SciReports aluminium Al neurological damage CBD THC cannabis
By Neha MathurJun 20 2023Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers assessed the potential protective effect of cannabidiol - and delta-9-tetrahydrocannabinol -based oils derived from Cannabis sativa plants against aluminum -induced neurotoxicity in the zebrafish animal model.
Any changes in the CholNS are, thus, responsible for many neurodegenerative disorders, such as Parkinson's, Alzheimer's disease , and multiple sclerosis . Aluminum , the third most abundant metal on the earth, toxicate the CholNS system. In high concentrations, Al could lead to intoxication and cause neurotoxicity. However, its physiological action as a neurotoxic compound is unclear.
Related StoriesIn addition, they evaluated the effect of these oils on AChE activity as the marker of CholNS function and the antioxidant enzymes, superoxide dismutase , catalase , and glutathione S-transferase . Zebrafish exposed to Al showed an anxiety-like behavior, which declined their social interaction, most likely due to a decrease in AChE resulting in neurotoxicity. Exposure to Al in the presence of the CBD- and THC-rich oils negated the adverse effects of the metal, suggesting an antioxidant and neuroprotective effect of these oils.
In the SPT test, Al decreased the interaction with the conspecifics. However, when applied with the THC-rich oil, test animals resumed their social interaction. While the THC-rich oil reversed the effect on cholinergic signaling and behavior or helped resume AChE activity, neither THC- nor CBD-rich oils reversed the anxiety-like pattern, likely because different behavioral paradigms were used in the study experiments.
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