Long COVID refers to a set of symptoms — such as severe fatigue, brain fog, headache, muscle pain and sleep problems — that can persist for weeks or months after the active infection has ended.
A healthcare worker administers a COVID-19 test at a Unidos En Salud community vaccination and testing site in the Mission District of San Francisco, Aug. 1, 2021.
While preliminary research suggests that it is, in fact, possible for a breakthrough case to lead to symptoms that can persist for weeks to months, there are still more questions than answers. What percent of breakthrough cases result in lingering symptoms? How many of those people recover? Are the persistent symptoms after breakthrough infection as severe as those that occur in the unvaccinated?
But the study’s authors caution against drawing too many conclusions from the research. The sample size — just seven patients — is small. And the research was designed to study antibody levels in the infected, said Dr. Gili Regev-Yochay, director of the infectious disease epidemiology unit at Sheba Medical Center. It was not designed to study the risk of long COVID after a breakthrough infection.
“I’m going to take it at face value that 1 in 5 people, six weeks after a breakthrough case, continued to feel crummy,” Wachter said. “That’s enough to make me want to wear two masks when I go into the grocery store, which is not that burdensome anyway.” Diana Berrent, founder of Survivor Corps, a Facebook group for people affected by COVID-19 that has about 171,000 members, took an informal poll and found 24 people who said they had lingering symptoms after a breakthrough infection. It is not a scientific sample, and the cases have not been validated, but the poll shows the need for more data on breakthrough cases, Berrent said.
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