Can beer intake improve heart health following oxidative injury? antioxidants_OA heart health myocardial tissue myocardialtissue beer fermented fermenteddrinks oxidativeinjury
By Bhavana KunkalikarMay 16 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Antioxidants journal, researchers examined the impact of antioxidants found in fermented beverages on tissue transcriptomics and the progression of cardiovascular disease at a molecular level.
Background Polyphenols found in fermented beverages like wine and beer have been proven to provide protection against oxidative stress. Cardiovascular disease is significantly impacted by oxidative stress, which is responsible for its development and advancement. Female pigs were fed a hypercholesterolemic diet and divided into different groups. The low-dose beer group was administered 12.5 g of alcohol per day, the moderate-dose beer group was administered 25 g of alcohol per day, and the control group was given a hypercholesterolemic diet without any beer.
The researchers conducted a gene set enrichment analysis to rank genes based on their fold-change between low- and moderate-dose beer regimes. Results The heart transcriptome was altered in a dose-dependent manner by beer consumption. The low-dose beer had a minor impact on the heart's gene expression, but the moderate-dose beer had a significant effect on the transcriptome compared to the control.
The team also discovered contrasting outcomes for low and moderate beer intake when Gene Ontology terms "positive regulation of inflammatory response" and "humoral immune response" were explored.
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