Breast cancer and MEN1: exploring the connection PLOSONE UTAustin breastcancer MEN1 cancer womenshealth genomics mRNA
By Hugo Francisco de SouzaJul 17 2023Reviewed by Lily Ramsey, LLM In a recent publication in the PLOS One Journal, researchers evaluated the role of Multiple Endocrine Neoplasia 1 messenger ribonucleic acid in breast cancer. Their results revealed that MEN1 gene expression was significantly higher in tumor tissue when compared to normal cells, with expression primarily localized in the nuclear region.
As of 2020, this disease has been responsible for over 685,000 deaths per year globally, making research into the pathways and mechanisms of the condition essential. Related StoriesInterestingly, upregulation of the gene, and its consequential increase in menin, have been reported to reverse this effect, hastening breast cancer proliferation and seemingly imparting drug and therapy resistance to tumors.
Researchers isolated RNA from aliquotes to synthesize a cDNA library for mRNA expression analyses. The cDNA library was processed through a real-time polymerase chain reaction using MEN1-specific primers for RNA amplification. Study findings The present study revealed that MEN1 expression was upregulated in nearly 63% of breast cancer patients. Of the 61 estrogen receptor-positive women in the study, 46 showed MEN1 mRNA overexpression, suggesting a strong association between mRNA upregulation and ER status.
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