Blood samples from healthy individuals have pre-existing anti-SARS-CoV-2 IgGs and IVIg may be an effective therapy for severe COVID-19 BioMedCentral SARSCoV2 COVID19 coronavirus covid antibodies
By Dr. Liji Thomas, MDNov 14 2022Reviewed by Danielle Ellis, B.Sc. This is in the form of immunoglobulin G antibodies directed against the coronavirus disease 2019 pathogen, namely, the severe acute respiratory syndrome coronavirus 2 .
There is a lack of effective therapies against this virus. The current study, published in Virology Journal, examines the utility of IVIg in COVID-19. Such therapy has already come into clinical use against a host of inflammatory diseases, including allergies, autoimmune and neurological diseases, and atopy, but also in the previous outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome .
The study took place from January 11 to February 28, 2020, including a small cohort of 23 patients who had severe COVID-19. All were admitted to the intensive care unit in the same hospital. Nearly 200 healthy volunteers were also included in the study as controls, none of whom were positive for the virus.
Again, females were much more likely to be seropositive for one of the peptides than males, at over 80% vs. 60%, respectively. Finally, individuals over 50 were seropositive for one specific peptide, at over 90%, vs. younger people.
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