These “blastoids” could be used to develop new contraceptives with fewer side effects, or better fertility treatments.
don’t replicate blastocyst cells as well as the new blastoids do. What’s more, the team has already used its blastoids to reveal molecules that could be candidates for new contraceptives and fertility treatments.
A week after fertilization, developing human embryos implant into the uterus using a blastocyst, a spherical envelope of cells surrounding the cells that will become the embryo. To replicate this process, the team led by stem cell biologist Nicolas Rivron at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna looked to lab-grown human stem cells.
The researchers chemically inhibited molecular pathways involved in the cells’ growth and the timing of life cycle events. As a result,When the team put the blastoids on lab-grown cells from the lining of the uterus, the spheres adhered to the surface, re-creating a crucial step in early pregnancy. And the researchers identified a compound that prevents blastoid attachment as well as one that encourages it, revealing their potential as nonhormonal contraceptives or fertility treatments.
These blastoids aren’t thought capable of developing into humans. Still, the team did not let the models develop past 13 days, in accordance with guidelines for
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