A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer, a team led by researchers at The University of Texas at Austin has found.
Reviewed by Megan Craig, M.Sc.Oct 9 2023 In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy. The research is published in the journal Cancer Cell and could be a game changer for many cancer patients.
"In animal models, our drug lowers MTA back down to normal, and the immune system comes back on," said Everett Stone, a research associate professor in the Department of Molecular Biosciences and associate professor of oncology at Dell Medical School, who led the work."We see a lot more T cells around the tumor, and they're in attack mode.
The 9p21 deletion leads to the loss of some key genes in cancer cells. Gone are a pair of genes that produce cell cycle regulators -; proteins that keep healthy cells growing and dividing at a slow, steady rate. When those genes are lost, cells can grow unchecked. That's what makes them cancerous. Also deleted is a housekeeping gene that produces an enzyme that breaks down the toxin MTA.
Related StoriesTo create their drug candidate, Stone and his colleagues started with the helpful enzyme that's naturally produced by the body to break down MTA and then added flexible polymers.
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