A Yale researcher poised to start a crucial clinical trial received an ominous email from a pharmaceutical company. “There is undoubtedly a financial motivation,” he said—and there could be millions on the line.
The race to develop a COVID-19 vaccine is well underway, but given its extended timeline—12 to 18 months—the search for an existing drug to treat the virus is almost equally pressing. For many on the right, including the president, the method of choice was hydroxychloroquine, a malaria drug initially thought to combat the infection.
The drug is manufactured in Japan; Ono Pharmaceutical, a massive company headquartered in Osaka, has committed to providing enough camostat pills for 300 patients over the course of Vinetz’s study. All he needs is FDA approval for the trial and his staff can begin testing.
Vinetz said he interpreted the email to mean “you have to go through us.” “They seem to want me to have to work under their authorization,” he said. “I viewed it as a threatening email,” he reiterated. “There is undoubtedly a financial motivation.” He theorized that the company might be hoping to get camostat designated as an orphan drug. The Orphan Drug Act, which Congress passed in 1983, uses financial incentives to encourage the development of drugs that treat rare diseases.
“There was a rapid, vociferous, and powerful public outcry because the implications for possible profiteering were concerning,” Vinetz said of Gilead.an immunologist and allergist in New York City, noted that “Those are bad optics for the company during a pandemic, to have a monopoly on a lifesaving drug.”
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