Study findings are encouraging, but the population was not diverse, and only one dose of atorvastatin was examined.
events over 24 months of follow-up. There was no difference in the rates of incident HF between study groups . The number of serious related adverse events was low and was similar between groups.
Regarding the study's limitations, although 50% of the study population was female, there was no racial or ethnic diversity in the cohort. Also, in the STOP-CA study, atorvastatin was administered only at a dosage of 40 mg/day. Therefore, it was not possible to assess any potential effects with other doses or treatment durations.Anthracyclines treat a broad range of cancers and play an essential role in the anticancer therapy armamentarium.
The authors wrote that the design of the trial was not intended to reveal why statins offered protection against anthracycline-associated cardiotoxicity. Although these mechanisms are unclear, the data suggest that anthracyclines cause oxidative damage to heart cells. According to the scientists, the interventions proposed in the study were safe and did not affect hemodynamic parameters such as blood pressure. Moreover, they emphasized that statins do not pose a risk to oncology patients.Considering how complex the field of oncology is, choosing a treatment is often challenging, especially when the risk of adverse events is high.
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