Are men or women impacted more by adverse reactions to prescription drug treatments? univamu AdverseReaction PrescriptionDrugs Medicine
By Pooja Toshniwal PahariaOct 11 2022Reviewed by Aimee Molineux In a recent study published in Therapies, researchers presented an overview of sex-based differences in adverse drug reactions based on epidemiology, technique, and underlying mechanism data.
Sources of pharmacovigilance differences by sex Physiological differences between men and women regarding cardiac output and body composition affect pharmacokinetics, including drug absorption, biodistribution, metabolism, and clearance. In addition, females have greater gastric pH, slower GI transit, water content, plasma volumes, and blood flow to organs, leading to differential secretion of transporters and enzymes involved in drug metabolism among men and women.
Methods to assess sex-based differences in drug safety To examine the impact of sex on drug safety profiles, knowledge of drug use patterns in the general population and the general epidemiology of the event or condition of interest by sex is critical. The reporting behavior among men and women must be considered.
Women are at an increased risk of tigecycline antimicrobial-induced acute pancreatitis and antiretroviral drug-use ADRs, including lactic acidosis, elevated hepatic enzymes, insulin resistance and dyslipidemia. Nevirapine -induced rashes have been more common in women. Studies have reported an increased likelihood of cutaneous ADRs after exposure to anti-infectious drugs such as cotrimoxazole, pyrimethamine-sulfadoxine, and ampicillin.
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