In their first real-world test, parasite-targeting monoclonal antibodies—which have been effective in the lab—protected people in Mali against malaria.
The study’s monoclonal antibodies—labmade versions of a natural immune protein that can target the most deadly malaria parasite,—offer a potential new weapon in the armamentarium that might be used to protect children and pregnant women, another vulnerable group.
“This will help us to save more lives of children and pregnant women in African countries,” says epidemiologist Kassoum Kayentao, who presented the findings today at the annual meeting of the American Society of Tropical Medicine and Hygiene in Seattle and is first author on theFaith Osier, a malaria immunologist and vaccinologist at Imperial College London, calls the paper “hugely exciting.” Still, “I have quite a few ‘yes buts,’” she says.
Even if intravenously delivered monoclonal antibodies prevent disease really well, they have drawbacks, particularly costs, others note. “How much money does it cost to make a monoclonal antibody? Is production cost going to get cheaper and cheaper as the number of antibodies we’re making gets to be bigger and bigger?” asks Myron Cohen, an infectious disease specialist at the University of North Carolina, Chapel Hill, who has helped develop monoclonal antibodies against HIV and SARS-CoV-2.
Seder hopes a trial happening right now will address those concerns. His lab has already developed another antibody, L9LS, that targets the same protein region but is three times more powerful than CIS43LS. In a human challenge study in U.S. adults published in August, L9LSwhen given subcutaneously—as an injection under the skin—which is far quicker and less cumbersome.
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