🗣'The DUP knows it must return to devolution, but the challenge is changing course after boxing itself into a corner for so long over Brexit.'
By all accounts it was a low-key local government election campaign - but the results were far from dull.
The conundrum for Sinn Féin is that the party has achieved its best ever result with a campaign that avoided mentioning its main goal of achieving a united Ireland. Once again the centre-ground party's successes were mostly to the east, with a breakthrough in nationalist-leaning councils west of the Bann still a work in progress.
A period in opposition following a revival of devolved government could be the only means of reversing this trajectory.Get the latest politics news and analysis in your inbox Want the biggest political stories sent straight to you?
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Sinn Fein wins but the DUP hasn't lost its mandate for Stormont boycottSinn Fein has become the largest party in local government - a seismic shift in Northern Irish politics and a blow to the DUP.
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Michelle O'Neill hails 'momentous' election and calls for return to powersharingMs O’Neill said the boycott of the Stormont Assembly by the DUP “cannot go on”.
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BBC Sport pundit is absolutely right on the money with his Newcastle United analysisBBC Sport pundit is absolutely right on the money with his NUFC analysis ahead of facing LCFC in their next premierleague clash NUFC EPL
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UmetaFlow: an untargeted metabolomics workflow for high-throughput data processing and analysis - Journal of CheminformaticsMetabolomics experiments generate highly complex datasets, which are time and work-intensive, sometimes even error-prone if inspected manually. Therefore, new methods for automated, fast, reproducible, and accurate data processing and dereplication are required. Here, we present UmetaFlow, a computational workflow for untargeted metabolomics that combines algorithms for data pre-processing, spectral matching, molecular formula and structural predictions, and an integration to the GNPS workflows Feature-Based Molecular Networking and Ion Identity Molecular Networking for downstream analysis. UmetaFlow is implemented as a Snakemake workflow, making it easy to use, scalable, and reproducible. For more interactive computing, visualization, as well as development, the workflow is also implemented in Jupyter notebooks using the Python programming language and a set of Python bindings to the OpenMS algorithms (pyOpenMS). Finally, UmetaFlow is also offered as a web-based Graphical User Interface for parameter optimization and processing of smaller-sized datasets. UmetaFlow was validated with in-house LC–MS/MS datasets of actinomycetes producing known secondary metabolites, as well as commercial standards, and it detected all expected features and accurately annotated 76% of the molecular formulas and 65% of the structures. As a more generic validation, the publicly available MTBLS733 and MTBLS736 datasets were used for benchmarking, and UmetaFlow detected more than 90% of all ground truth features and performed exceptionally well in quantification and discriminating marker selection. We anticipate that UmetaFlow will provide a useful platform for the interpretation of large metabolomics datasets. Graphical Abstract
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Alliance surge in Lisburn and Castlereagh with Indpendent to be King makerHowever, despite forecasts of a DUP decline the majority party keeps its top spot at Lagan Valley Island and maintained the 15 seats it won at the last local election.
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