Amid a Surge in RSV Cases, Hopes for a New Vaccine - MedicineNet Health News

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Amid a Surge in RSV Cases, Hopes for a New Vaccine - MedicineNet Health News
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New vaccine vs. RSV gives pediatricians hope.

The first RSV vaccine trial conducted in the United States in the 1960s turned out to be “horrible,” Glatt said, “and through lack of full understanding of immunology actually worsened things for patients.”

The mistake with the first vaccine candidate was that it created antibodies based on the F-protein's shape after it had already gotten into a human cell, said Liu. “That suddenly opened the gateways into RSV vaccine research, which has still proceeded very, very slowly because of concern and fear over antibody-dependent enhancement,” Poland said. “In the field of vaccinology, this is generating immense excitement, and rightfully so.”

For example, GSK announced at the October annual meeting of the Infectious Diseases Society of America that its RSV vaccine had been more than 90% effective in protecting seniors against the virus.

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