itemprop=description content=Research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has discovered that altering certain molecular interactions could yield new strategies for treating prostate cancer and related diseases.
Reviewed by Lily Ramsey, LLMOct 6 2023 Research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio has discovered that altering certain molecular interactions could yield new strategies for treating prostate cancer and related diseases.
The researchers determined that an optimum level of androgen receptor "multivalent interactions" likely is required for proper function. Multivalent interactions involve a simultaneous binding of multiple molecules on the same regulatory chromatin sites to control gene expression. The scientists also concluded that alterations of these interactions might underlie the cause and development of disease.
Zhijie "Jason" Liu, PhD, associate professor and CPRIT Scholar in Cancer Research with Mays Cancer Center and the Institute of Biotechnology of the Department of Molecular Medicine at UT Health San Antonio They observed that androgen receptors form local high-concentration "condensates" – membrane-less subunits that carry out specialized cell functions – through protein-clustering interactions. These are driven by certain multivalent interactions in response to androgen hormone stimulation.
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