An “all-in-one” vaccine currently in development could protect people from future Covid-19 variants, a study by researchers at the California Institute of Technology found.
, was done by scientists at Caltech and the University of Oxford who are working on developing the mosaic-8 vaccine, which aims to offer protection to a variety of coronaviruses
Researchers tested mice vaccinated with the Covid-19 shots as well as the mosaic-8 vaccine and found unvaccinated mice died when infected with SARS or Covid-19, while mice vaccinated only against Covid-19 survived the virus, but not SARS, and mice given the mosaic-8 vaccine survived both viruses. The mosaic-8 vaccine uses 60 fragments of eight strains of coronaviruses, including Covid-19, which was shown to induce a “broad spectrum” of antibodies in primates and genetically-engineered mice with human-like cell receptors to target coronavirus “spike proteins.”
The nanoparticle development has the potential to mitigate viral infection caused by known and future Covid-19 variants and other “viral spillovers,” according to the study. Caltech, which conducted the research in collaboration with WellCome Leap, is expected to start phase-one clinical trials over the next year using $30 million from the Coalition for Epidemic Preparedness Innovations.A similar experiment conducted at Caltech last year showed that the mosaic-8 vaccine induces mice to produce antibodies that react to a variety of coronaviruses in a lab dish.
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