An experimental Alzheimer's disease drug developed by Acumen Pharmaceuticals targeting a novel form of the toxic protein beta amyloid in the brain passed an early safety test and will advance to a larger trial, the company said on Sunday.
earlier this month after showing it could remove amyloid plaques and slow the advance of Alzheimer's in early-stage patients.
In the Acumen trial, 10.4% of treated participants developed a brain swelling condition known as ARIA-E associated with amyloid-targeting treatments. Of these, only one had symptoms, which resolved after the drug was stopped."Because this antibody targets oligimers but is not intended to target plaque, we didn't know if we would get any ARIA or not," said Siemers, adding that the ARIA cases may suggest the drug is having an effect.
People who got higher doses of the drug also showed a reduction in amyloid plaque after 6 to 12 weeks, the company said. Acumen said the study suggests the drug can be given as a monthly intravenous infusion.
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