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PHILADELPHIA — Every year, Katalin Karikó met with her University of Pennsylvania department chair to update him on her quest to treat disease with messenger RNA — fragile, inflammatory genetic molecules that were so difficult to work with that most scientists thought it was a waste of time.
But in an autobiography that comes out Tuesday, Karikó describes years of struggle to get her ideas accepted by Penn colleagues and the broader scientific community. Even after 2005, when she and Weissman published the first of several studies showing how mRNA could be used in a vaccine, she was rebuffed in her attempts to seek a tenured position, she says in “Breaking Through: My Life in Science,” published by Crown.
Karikó chafed under that system, instead aiming for a high-risk target — using mRNA to fight disease — that most of her peers thought was unattainable. She did it working in lowly, nontenured positions for more than two decades, finding a home in the labs of a few sympathetic colleagues who could spare the funds. Frustrated, she finally left Penn in 2013 for a German startup called BioNTech, which would one day collaborate with Pfizer to make the first COVID vaccine.“Dr.
In interviews, Barnathan and Langer said Karikó was not naive. She knew full well that her ideas meant nothing without money, whether at Penn or anywhere else. They said that at times, she may have hurt her cause with her blunt-spoken manner.
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