The team uncovered the mysterious relationship between the disease and the protein.
of The University of Melbourne, have solved a mystery about Parkinson’s disease, which can help create novel treatments for the disease.
Led by Ph.D. student Zhong Yan Gan and Professor David Komander from WEHI, used state-of-the-art cryo-electron microscopy to visualizePINK1 protein normally protects cells by demolishing and recycling damaged mitochondria. When there are defects in PINK1 or other components of this process, it prevents the replacement of the mitochondria thus starving the cell of energy.
PINK1 malfunctions are estimated to be important for young people who develop Parkinson’s due to hereditary mutations of the protein. “The team then used the images to create a “live-action” view of the activation of the protein, thus providing information about how Parkinson’s disease kills or impairs the nerves that produce dopamine. The research has also been published in“Many papers from laboratories around the world – including ours – have captured snapshots of the PINK1 protein," first author Zhong Yan Gan.
There are many ongoing studies regarding the currently untreatable Parkinson’s disease. A recent study conducted in UC San Francisco Weill Institute for Neurosciences analyzed 11 years' worth of data and scientists discovered a link between
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