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. Similar surges of the KIR-producing T cells in people fighting infections were also detected in 56 COVID-19 patients: the sicker the patients were, the more of the cells they harbored.
The researchers also looked at genetically altered mice that had 50 percent to 75 percent fewer suppressive CD8 cells than normal mice to see how much protection the cells provide against autoimmunity. The rodents experienced kidney inflammation after being exposed to viruses that can cause autoimmune illness. Control mice, on the other hand, showed no signs of autoimmune illness after infection.
Based on these experiments, the paper provides solid data that these cells exist in humans, and this could indicate that techniques that enhance the number of cells in the bodyStudy Abstract: T cells expressing inhibitory killer cell immunoglobulin-like receptors are the human equivalent of Ly49 regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases.
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