A good night's sleep promotes immunity Immunity Sleep Hematopoiesis InnateImmunity Inflammation Neuroscience JExpMed IcahnMountSinai MassGeneralNews ColumbiaMed
Study: Sleep exerts lasting effects on hematopoietic stem cell function and diversity. Image Credit: Yuganov Konstantin / Shutterstock
Despite the plethora of evidence linking sleep to various disease outcomes and overall health, chronic sleep disruption is a predominant issue of the modern age. Recent findings that suggest that catch-up sleep does not compensate for disrupted sleep further emphasize the role of sleep on human health. However, the cellular and epigenetic mechanisms through which insufficient sleep impacts the immune system remain unexplored.
Circulating leukocytes were analyzed through flow cytometry. Enzyme-linked immunosorbent assay was used to measure the levels of granulocyte colony-stimulating factor , macrophage colony-stimulating factor , tumor necrosis factor alpha , interleukin 6 , and interleukin 1 beta . Earlier research has shown that sleep disorders such as insomnia and obstructive sleep apnea caused epigenetic modifications in circulating leukocytes, the cardiovascular system, altered deoxyribonucleic acid methylation in the liver and muscle tissue, and caused rapid epigenetic aging of blood leukocytes. The results from this study provided evidence that these epigenetic modifications are partially maintained and impact future immune function and disease pathology.
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