Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser . In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.Nearly 40% of human proteins are predicted to contain intrinsically disordered regions , which can remain unfolded or adopt diverse conformational states in the cell.
Existing methods to identify intrinsically disordered proteins associating with chromatin have been limited to antibody-based assays. Now, work inintroduces DisP-seq, an improved method to map the genome-wide binding of DNA-associated proteins that contain IDRs. This approach uses a small molecule to precipitate proteins containing IDRs along with the genomic regions to which they are bound, followed by massively parallel sequencing of the associated DNA.
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