3D maps shed new light on complex systems NBTintheNews via Labmate_online
A team of scientists from Helmholtz Munich, the LMU University Hospital and the Ludwig-Maximilians Universität München have found a way of using of standard antibodies to map whole bodies of mice using fluorescent markers, especially useful for studies of body-wide structures such as the nervous system.
Ali Ertürk explains the vision behind the project: “Knowing where each protein is expressed in the body is essential for developing a comprehensive understanding of how the body works and what goes wrong in complex diseases”. DISCO, the researchers were able to create detailed maps of cellular structures leading to entire mouse body atlases, focusing on the nervous system, lymphatic vessels, blood vessels and immune cells.
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